The Estronex Profile helps determine your risk of developing estrogen sensitive cancers, including breast, cervical, uterine, and prostate, by measuring six important estrogen metabolites.
The ratio of estrogens is determined using a simple, first-morning urine collection.
What is measured in this test?
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The “Good” Estrogen
- 2-hydroxyestrone (2-OHE) - Sum of 2-Hydroxyestrone (2-OHE1) and 2-Hydroxyestradiol (2-OHE2) – this “good” estrogen is ideal in high levels to reduce cancer growth.
- 2-hydroxyestradiol (2-OHE2) - exhibits anti-carcinogenic effects
- 2-methoxyestrone (2-OMeE1) - shown to have anti-cancer effects
- 4-methoxyestrone (4-OMeE1)- non-cancerous
The “Bad” Estrogen
- 16-α-hydroxyestrone (16α-OHE1) – considered a “bad” estrogen, 16α-OHE1 encourages tumor development and is therefore ideal in low levels.
- 4-hydroxyestrone (4-OHE1) – may react negatively with damaged DNA.
The 2:16 Ratio
- 2-OHE:16α-OHE1 (2:16 ratio) - 2:16 ratios less than 2 indicate increasing long-term risk of breast, cervical, and other estrogen sensitive cancers. Importantly, studies also indicate that this risk is modifiable, implying that nutritional interventions can help raise Estronex 2:16 ratios and decrease long-term risk.
- 2-OHE1:2-OMeE1 – a high level of 2-OHE1:2-OMeE1 may also indicate imbalanced estrogen metabolism and low activity in the COMT gene. Evaluation of methylation activity is recommended.
A woman’s unique biochemical makeup determines how much of each form of estrogen is produced. Studies have shown the ratio of these two forms of estrogen provides an important indication of the risk of developing breast cancer. Learn more about this risk ratio.
“ I offer the Estronex testing to all my patients because it enables them to evaluate their personal risk for developing breast, ovarian, and colon cancer based on how their body is detoxifying estrogen. I tell my patients that no matter how you get the hormones, whether it is from what your body produces naturally, what hormones you take in such as with hormonal therapy, or what you are getting from your environment such as with xenoestrogens, it is important to know what your body is doing with it. With that knowledge patients can be put in charge of their own health and work dietarily to reduce their risk. This is very empowering! ”
- Anna M. Cabeca, DO, FACOG, DAARM